SHA 094. Aldactone in patients with heart failure: Friend or foe?
نویسندگان
چکیده
منابع مشابه
Cyclooxygenase-2 induction in congestive heart failure: friend or foe?
Cyclooxygenase-2, like the other member of the COX family, COX-1, is a bifunctional enzyme that catalyzes the conversion of arachidonic acid to PGG2 via COX activity and PGG2 to PGH2 via peroxidase activity. PGH2 is the precursor for PGs, prostacyclin, and TXA2. Hence, COX-2 occupies a central position in the biosynthesis of proinflammatory PGE2 and vasoactive prostacyclin and TXA2. COX-2 share...
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I agree with Dr MT Naughton’s interesting opinion expressed in ‘Cheyne-Stokes respiration: friend or foe?’ in his recent opinion in Thorax. Central sleep apnoea with Cheyne-Stokes respiration (CSA-CSR) indeed has multiple features more likely to be compensatory than injurious in heart failure (HF). His view, however, seems to lack insight into the heart–lung interaction in CSA-CSR, and reminds ...
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Supplemental oxygen, a therapy that has been used for more than a century, is recommended in all practice guidelines in the management of hypoxemic (peripheral oxygen saturation <90% to 94% or partial arterial oxygen pressure <60 mm Hg) patients with acute heart failure, but its use in normoxemic patients is controversial. Several pre-clinical and early clinical studies have shown the detriment...
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Hypertension and heart failure are marked by activation of both the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system. These forms of neurohumoral activation, in turn, have deleterious effects on the heart, kidney, and other target organs, worsening the prognosis in these disease states. Pharmacological agents that interrupt the RAAS are useful in both improving hem...
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Particularly in the field of advertising and in popular scientific journals, antioxidants such as β-carotene (from carrots) or lycopenes (from tomatoes) and the vitamins C and E are one-sidedly portrayed as substances capable of offering protection against cancer or ageing because they diminish or prevent the effects of free radicals. However, free radicals should by nomeans be considered as be...
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ژورنال
عنوان ژورنال: Journal of the Saudi Heart Association
سال: 2011
ISSN: 1016-7315
DOI: 10.1016/j.jsha.2011.02.095